Select (or delete) All Guides
It’s easy to delete a guide on your InDesign page: Just select it with the Selection or Direct Selection tool and press Delete. But what if you want to delete all your guides? Here’s one of my favorite hidden shortcuts: Command-Option-G/Ctrl-Alt-G. That selects all the guides on the current spread. Now you can press Delete to get rid of all of them at once.
Alternately, you can choose Layout > Create Guides, turn on the Remove Existing Ruler Guides checkbox, and click OK. That also removes the guides from your spread.